We have a new and exciting opportunity for a Postdoctoral Researcher to join the Hammond group, based at the Old Road Campus in Headington. The ‘chemical biology tools for investigating the chemistry of REDOX stress’ programme grant brings together ten academic groups, located across three sites in Oxford and King’s College London, and industrial partners including GSK and GE Healthcare. The aim of the programme is to develop tools to image and study the REDOX environment in cells, tissues and in vivo. We will use a range of imaging modalities including fluorescence-based techniques to study cellular detail, and PET- and MRI-based approaches to enable in vivo imaging. The ultimate aim of the programme is to use the REDOX environment to better understand and predict disease. Specifically, this role will be focused on the validation of novel probes for the measurement of REDOX state in cell lines. Importantly, we will ask how changes to individual parameters, such as oxygen, impact other REDOX components and cellular metabolism.
Professor Hammond’s research is focused on tumour hypoxia and how this impacts treatment response. Regions of hypoxia (low oxygen) occur to some degree in most solid tumours. Most importantly, hypoxia is a well-established marker of poor patient prognosis. This is in part due to increased therapy resistance in hypoxic tumours. The Hammond lab has been responsible for describing the DNA damage response, which is largely a result of replication stress, in hypoxic conditions. Selected publications can be found on the group website (www.rob.ox.ac.uk/research/ester-hammond) or for a comprehensive list use hammond_em to search Pubmed. Professors Hammond and Conway (Department of Chemistry, Oxford University) have been collaborating for approximately 10 years, this collaboration began with the generation of hypoxia-activated molecularly targeted pro-drugs to combat tumour hypoxia.
The postholder’s responsibilities will include collaborating and communicating with the PI, Co-I and other programme researchers, to deliver the overall aims of the programme, as well as managing own academic research and administrative activities. This involves small-scale project management, to co-ordinate multiple aspects of work to meet deadlines and contributing ideas for new research projects. You will also be expected to prepare high-quality paper manuscripts, reporting the research completed by the programme. You will possess (or be near to completing) a PhD/DPhil in molecular biology, biochemistry, biology or a related science (or have submitted your thesis prior to taking up the post). A high level of technical competence and experience in molecular/cell biology methods and techniques, (for example CRISPR), along with demonstrable competence and success in the PhD research area (and postdoctoral work if appropriate), are also essential for this role.
This is a full-time post, funded for 3 years in the first instance.
All applicants must complete a short online application form and upload a CV and supporting statement.
The closing date for applications is 12.00 noon on Wednesday 28th August 2019.