We are seeking a highly motivated and enthusiastic Postdoctoral Scientist to join us at the Centre for Medicines Discovery, at the Nuffield Department of Medicine, to work on an exciting translational anticancer research project located at the interface between academia and industry.
You will be responsible for establishing efficient expression and purification systems of RNA modifying enzymes, and help unravel the molecular mechanisms of substrate recognition and allosteric regulation by co-crystallization of chemical fragments/ligands, substrates or complex partners. You will develop biochemical assays and study the interaction of lead compounds with these protein interaction domains and help understand the SAR (structure activity relationship) of compound classes with the goal to develop highly selective first- in-class chemical probes. You will supervise junior and technical staff, while also coordinating this project with other internal and external partners and provide progress reports. You will be responsible for contributing to the scientific output by publishing high quality manuscripts and by representing the group at international scientific meetings.
It is essential that you hold a PhD (or near completion) in protein biochemistry and structural biology with an excellent academic track record, including at least one first author publication in an expert journal. You will have experience in protein crystallization and optimization of protein crystals and experience in cryo-electron microscopy. It is essential you have significant experience in cloning and recombinant protein purification using bacterial, insect cell and mammalian host systems and also demonstrable experience in biochemical assay development using various read-outs and biophysical ligand binding. You will have excellent organisation and project management skills, and have excellent verbal presentation and written communication skills, including experience independently writing scientific reports and manuscripts as well as project proposals.
Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Applications should not include PDF copies of published research articles.
This position is offered full time on a fixed term contract for 12 months, and is funded by DBT.
Only applications received before 12 midday on Monday 22 August 2022 will be considered. Please quote 158581 on all correspondence.