The researcher will join a collaborative effort between DPAG and WRH, funded by an award from the Research Innovation Fund of Pancreatic Cancer UK.

 

To expand, pancreatic cancer cells must first adapt to the acidic conditions in tumours by implementing adaptations involving ‘survival genes’, which also represent vulnerabilities for new therapies to target. We propose to derail cancer progression using DNA-binding molecules, called triplex-forming oligonucleotides (TFOs), that inactivate these survival genes in the most metabolically active and acid-resistant cells responsible for driving aggressive disease.

 

The successful applicant will lead on pioneering research efforts to bring the latest therapeutic cargo delivery and TFO technology to eliminate pancreatic cancer cells. Work at this innovation stage is entirely in vitro. The project, funded by PCUK’s Research Innovation Fund, is a first step towards delivering precision medicine to target a metabolic vulnerability in cancer.

 

The successful applicant will have experience in working with nucleic acids, in delivering constructs to cells, and in performing assays; demonstrable skills in cell culture are essential; experience in developing therapy is desirable, although training will be provided, if necessary. Applicants must hold, or be close to completion of, a PhD/DPhil in a relevant field, such as biochemistry, molecular biology, oncology, or chemistry

 

The fixed term post is available from 01 July 2024. The post will be based in The Department of Physiology Anatomy & Genetics, Sherrington Building, Sherrington Rd, Oxford OX1 3PT

 

Informal enquiries may be directed to the DPAG HR Team – hr@dpag.ox.ac.uk  

 

Closing date for applications is midday on 22 May 2024

 

Interviews are likely to be held on the week commencing 03 June 2024

 
 

Applications are particularly welcome from women, black and minority ethnic candidates who are under-represented in academic posts in Oxford.

 

We, as a Department and Community, will be considerate and welcoming of all people, regardless of age, disability, gender reassignment, marriage and civil partnership, pregnancy and maternity, race, religion or belief, sex, sexual orientation, gender identity, and socio-economic background. We acknowledge societal inequalities and how these impact us, and those around us, personally and professionally. – DPAG Statement of Inclusion