Contract type: Fixed-term contract until 30th June 2026

 

We are looking for a postdoctoral researcher to work in Translational Research Immunology Group (TRIG) on translational, collaborative project funded by EU.  You will be placed in the Institute of Developmental and Regenerative Medicine on the Old Road Campus working in a close collaboration with the Oxford Kidney Pathology group.

 

You will be part of a bigger EU-funded project which goal is to develop a safe and efficient cell therapy based on genome edited T cells for IgA nephropathy (IgAN). IgAN is the most common glomerulonephritis; IgA-rich complexes are deposited in renal glomeruli, leading to renal failure a third of cases, but there are currently no effective treatments, so this an area of significant unmet need. Redirected T cells offer the potential to specifically target pathogenic IgA1 producing cells.

 

You will work closely with members of TRIG and Oxford Kidney Pathology groups, including students, other post-docs and research assistants as well as international collaborators within the EU consortium.  You will be responsible for testing T cell therapeutics developed by our consortium, using in vivo models of glomerular immune complex disease as well as the establishment of a novel model for IgA Nephropathy.  Additionally, you will contribute to spatial transcriptomics and proteomics in human IgAN kidney samples.

 

You will hold a PhD (or be near to completion: thesis submitted) in a relevant area at the time of application and will have extensive experience in immunology or kidney disease field.  Experience with cell culture techniques, animal models, molecular techniques is required.  . You will have demonstrated the ability to work independently within projects, with the ability to communicate results clearly and succinctly in presentations, manuscripts and grant applications.  Experience with flow cytometry and genetic editing techniques as well as knowledge of kidney disease are desirable.

 

This full-time post is available immediately and is fixed-term until June 2026 in the first instance.

 

If you would like to discuss this role, please contact Fadi Issa, fadi.issa@nds.ox.ac.uk.

 

Applications for this vacancy are to be made online. You will be required to upload a supporting statement, setting out how you meet the selection criteria, curriculum vitae and the names and contact details of two referees as part of your online application. Please quote reference NDSA926 on all correspondence.

 

Only applications received before noon 10 May 2024 can be considered.

 

Interviews will be held on Friday 24 May 2024.