Applications are invited for a Postdoctoral Researcher in genetic disorders of chromatin function as part of a new research group led by Dr Robert Beagrie, at the Wellcome Centre for Human Genetics, Nuffield Department of Medicine.

 

You will be responsible for contributing to the research group’s goal of understanding how mutations in chromatin organising genes cause disease. Your project will specifically examine how mutations in Nipbl cause the heart and brain defects seen in Cornelia de Lange syndrome. You will conduct laboratory experiments to test hypotheses, review and refine working hypotheses as appropriate, contribute ideas for new research projects and develop ideas for generating research income. You will manage your own academic research and administrative activities, adapt existing methods and develop new scientific techniques, computational approaches and/or experimental protocols. You will keep detailed, accurate and comprehensible electronic records of experimental and computational work and communicate progress and difficulties in the research project to Dr Beagrie and the wider research group. 

 

It is essential that you hold a PhD/DPhil (or be close to completion) in biology, biochemistry, genetics, bioinformatics or a related subject. You will have strong research experience in at least one of the following areas: chromatin, gene regulation or congenital disease, and will have hands on experience generating or analysing genomics datasets. You will demonstrate a clear interest in learning how to generate Genome Architecture Mapping data and integrate it with single-cell and/or spatial transcriptomics data. It is essential that you have excellent communication skills and can work collaboratively as part of a team. Whilst you will be expected to conduct both laboratory experiments and computational analyses, applications are strongly encouraged from applicants lacking experience in one or other of these areas.

 

Applications for this vacancy are to be made online and you will be required to upload a supporting statement and CV as part of your online application.  Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience.

 

This position is offered full time (part time hours considered minimum 60% FTE) on a fixed term contract for 2 years with a possibility of extension, and is funded by Wellcome.

 

Only applications received before 12 midday on Wednesday 6 July 2022 will be considered. Please quote 158337 on all correspondence.